<![CDATA[Diabetes Complications]]> https://alpha.eurekaselect.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Wed, 19 Feb 2025 18:12:59 +0000 <![CDATA[Diabetes Complications]]> https://alpha.eurekaselect.com https://alpha.eurekaselect.com <![CDATA[Combining Imaging and Drug Delivery for Cancer Treatment]]>https://alpha.eurekaselect.comchapter/13659 <![CDATA[Combined Interventions on Diabetes]]>https://alpha.eurekaselect.comchapter/13644 <![CDATA[Herbal Extracts from Carica papaya and Azadirachta indica: What Role for ROS in Cancer Cell Lines?]]>https://alpha.eurekaselect.comchapter/13172

The human body is constantly exposed to free radicals arising from exogenous and endogenous origins, which cause oxidative stress. Oxidative stress is closely related to various diseases, including cancer. There are many evidences that ROS are pivotal in cancer progression (via damage of DNA leading to genomic instability) and regression (via cell death induction through oxidative stress burst). Antioxidants stabilize free radicals and, in turn, prevent the oxidative stress, playing a key role in protection of the body, In this context, natural plants-derived antioxidants are universally considered very important for the prevention and treatment of oxidative stress and cancer. However, a dual role of plants in ROS generation or scavenging is recognized as plants extracts can also increase ROS production in the cells. Consequently, the role of plant extracts in ROS balancing inside cancer cells is a very fascinating feature in phytotherapy.

Among the plants reported in traditional medicine as a very panacea in active compounds, Carica papaya and Azadiracta indica (also known as Neem) extracts from different parts (leaves, seeds, fruits, etc.) are scientifically validated in the treatment of several diseases, including cancer. In this context, the two plants have different impact on cancer cell lines. In particular hydro-alcoolic extract of Neem leaves shows a pro-oxidant activity in hepatoma HepG2 cells, whereas water extract of C. papaya seeds exerts an anti-oxidant activity in leukemia HL-60 cells. Neem extract is unable to quench oxidative stress induced on HepG2 and synergizes with hydrogen peroxide (H2O2) in inducing cell death. Conversely, C. papaya extract quenches ROS induced by H2O2 in HL-60 cells but at the same time negatively affects cell viability.

These evidences corroborate the idea that the extracts from plants could act in patients with cancer to modulate oxidative homeostasis and obtain benefit during cancer therapy.]]>
<![CDATA[Industrial Uses of MAPs: The Pharmaceutical Sector]]>https://alpha.eurekaselect.comchapter/11096 <![CDATA[Drug Delivery to the Brain by Liposomal Carrier Systems]]>https://alpha.eurekaselect.comchapter/10708 <![CDATA[Interaction of Laser Beams with Medicine Solutions in Bulk]]>https://alpha.eurekaselect.comchapter/10648 <![CDATA[Metabolic Syndrome and Bioactive Compounds]]>https://alpha.eurekaselect.comchapter/10395

In Chapter 9 of this same book, we have already explained in detail, the main concepts about Mediterranean diet and bioactive compounds and diabetes.

In this chapter, we update the evidence about dietary bioactive compounds with potential in preventing / treating the Metabolic Syndrome. We will only focus on the studies where the evidence is relevant, not on the multiple studies in vivo, very interesting indeed, but with no current clinical relevance.

Bioactive compounds should be of the greatest interest because of their multiple positive effects on health, prevention of Metabolic Syndrome related diseases or lowering their complications.]]>

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